Finally got serial ports working, win7 host, if you have "Failed to attach the USB device (E_INVALIDARG)" issues then try deleting this win7 registry key, fixed mine. HKEY_LOCAL_MACHINE\SYSTEM\CurrentControlSet\Control\Class\{36FC9E60-C465-11CF-8056 ...
VirtualBox Failed to attach the USB device to the virtual machine
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VirtualBox Failed to attach the USB device to the virtual machine
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