![Schematic representation of the physiological population PK model for... | Download Scientific Diagram Schematic representation of the physiological population PK model for... | Download Scientific Diagram](https://www.researchgate.net/publication/326698494/figure/fig1/AS:962139091136529@1606403243417/Schematic-representation-of-the-physiological-population-PK-model-for-midazolam-and-the.png)
Schematic representation of the physiological population PK model for... | Download Scientific Diagram
![Discussions on the hepatic well‐stirred model: Re‐derivation from the dispersion model and re‐analysis of the lidocaine data | Semantic Scholar Discussions on the hepatic well‐stirred model: Re‐derivation from the dispersion model and re‐analysis of the lidocaine data | Semantic Scholar](https://d3i71xaburhd42.cloudfront.net/5b18898ebbe2342b515b13723085295e277a598b/2-Figure1-1.png)
Discussions on the hepatic well‐stirred model: Re‐derivation from the dispersion model and re‐analysis of the lidocaine data | Semantic Scholar
![Discussions on the hepatic well‐stirred model: Re‐derivation from the dispersion model and re‐analysis of the lidocaine data | Semantic Scholar Discussions on the hepatic well‐stirred model: Re‐derivation from the dispersion model and re‐analysis of the lidocaine data | Semantic Scholar](https://d3i71xaburhd42.cloudfront.net/5b18898ebbe2342b515b13723085295e277a598b/6-Table2-1.png)
Discussions on the hepatic well‐stirred model: Re‐derivation from the dispersion model and re‐analysis of the lidocaine data | Semantic Scholar
Interpretation of Non-Clinical Data for Prediction of Human Pharmacokinetic Parameters: In Vitro-In Vivo Extrapolation and Allom
![Precisely adjusting the hepatic clearance of highly extracted drugs using the modified well-stirred model - ScienceDirect Precisely adjusting the hepatic clearance of highly extracted drugs using the modified well-stirred model - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S0753332221006375-ga1.jpg)
Precisely adjusting the hepatic clearance of highly extracted drugs using the modified well-stirred model - ScienceDirect
![Discussions on the hepatic well‐stirred model: Re‐derivation from the dispersion model and re‐analysis of the lidocaine data | Semantic Scholar Discussions on the hepatic well‐stirred model: Re‐derivation from the dispersion model and re‐analysis of the lidocaine data | Semantic Scholar](https://d3i71xaburhd42.cloudfront.net/5b18898ebbe2342b515b13723085295e277a598b/7-Figure4-1.png)
Discussions on the hepatic well‐stirred model: Re‐derivation from the dispersion model and re‐analysis of the lidocaine data | Semantic Scholar
![Discussions on the hepatic well-stirred model: Re-derivation from the dispersion model and re-analysis of the lidocaine data - ScienceDirect Discussions on the hepatic well-stirred model: Re-derivation from the dispersion model and re-analysis of the lidocaine data - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S0928098718303762-t1.jpg)
Discussions on the hepatic well-stirred model: Re-derivation from the dispersion model and re-analysis of the lidocaine data - ScienceDirect
![Discussions on the hepatic well-stirred model: Re-derivation from the dispersion model and re-analysis of the lidocaine data - ScienceDirect Discussions on the hepatic well-stirred model: Re-derivation from the dispersion model and re-analysis of the lidocaine data - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S0928098718303762-gr5.jpg)
Discussions on the hepatic well-stirred model: Re-derivation from the dispersion model and re-analysis of the lidocaine data - ScienceDirect
![nsatmi on Twitter: "肝代謝のみで消失する薬物の経口投与で、AUCが2倍に上昇する場合。(消化管からの吸収率100%、well- stirred modelに従う) ・肝クリアランスが1/2になる さらに ・非結合形分率が1/2になる ・肝固有クリアランスが1/2になる *肝固有クリアランス ... nsatmi on Twitter: "肝代謝のみで消失する薬物の経口投与で、AUCが2倍に上昇する場合。(消化管からの吸収率100%、well- stirred modelに従う) ・肝クリアランスが1/2になる さらに ・非結合形分率が1/2になる ・肝固有クリアランスが1/2になる *肝固有クリアランス ...](https://pbs.twimg.com/media/EMPmlOTU0AAZ0HD.png:large)
nsatmi on Twitter: "肝代謝のみで消失する薬物の経口投与で、AUCが2倍に上昇する場合。(消化管からの吸収率100%、well- stirred modelに従う) ・肝クリアランスが1/2になる さらに ・非結合形分率が1/2になる ・肝固有クリアランスが1/2になる *肝固有クリアランス ...
![Discussions on the hepatic well-stirred model: Re-derivation from the dispersion model and re-analysis of the lidocaine data - ScienceDirect Discussions on the hepatic well-stirred model: Re-derivation from the dispersion model and re-analysis of the lidocaine data - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S0928098718303762-gr2.jpg)
Discussions on the hepatic well-stirred model: Re-derivation from the dispersion model and re-analysis of the lidocaine data - ScienceDirect
![PDF) Discussions on the hepatic well-stirred model: Re-derivation from the dispersion model and re-analysis of the lidocaine data PDF) Discussions on the hepatic well-stirred model: Re-derivation from the dispersion model and re-analysis of the lidocaine data](https://i1.rgstatic.net/publication/326965255_Discussions_on_the_hepatic_well-stirred_model_Re-derivation_from_the_dispersion_model_and_re-analysis_of_the_lidocaine_data/links/5bc64672299bf17a1c55d0cc/largepreview.png)
PDF) Discussions on the hepatic well-stirred model: Re-derivation from the dispersion model and re-analysis of the lidocaine data
![Hepatic clearance concepts and misconceptions: Why the well-stirred model is still used even though it is not physiologic reality? - ScienceDirect Hepatic clearance concepts and misconceptions: Why the well-stirred model is still used even though it is not physiologic reality? - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S0006295219302801-gr2.jpg)
Hepatic clearance concepts and misconceptions: Why the well-stirred model is still used even though it is not physiologic reality? - ScienceDirect
![PDF) Discussions on the hepatic well-stirred model: Re-derivation from the dispersion model and re-analysis of the lidocaine data PDF) Discussions on the hepatic well-stirred model: Re-derivation from the dispersion model and re-analysis of the lidocaine data](https://www.researchgate.net/profile/Jin-Dong-5/publication/326965255/figure/tbl1/AS:682452758585347@1539720825504/Comparison-of-the-well-stirred-models_Q320.jpg)
PDF) Discussions on the hepatic well-stirred model: Re-derivation from the dispersion model and re-analysis of the lidocaine data
nsatmi on Twitter: "well-stirredモデルによる分類整理 肝血流律速にしても、肝代謝能律速にしても、AUCに影響を与える因子は、やっぱり ・非結合形分率 ・肝固有クリアランス 肝血流の変動は、吸収↓と消失↓で相殺されるため、AUCに関与しません。 https://t.co ...
![Discussions on the hepatic well-stirred model: Re-derivation from the dispersion model and re-analysis of the lidocaine data - ScienceDirect Discussions on the hepatic well-stirred model: Re-derivation from the dispersion model and re-analysis of the lidocaine data - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S0928098718303762-ga1.jpg)
Discussions on the hepatic well-stirred model: Re-derivation from the dispersion model and re-analysis of the lidocaine data - ScienceDirect
![Hepatic clearance concepts and misconceptions: Why the well-stirred model is still used even though it is not physiologic reality? - ScienceDirect Hepatic clearance concepts and misconceptions: Why the well-stirred model is still used even though it is not physiologic reality? - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S0006295219302801-ga1.jpg)
Hepatic clearance concepts and misconceptions: Why the well-stirred model is still used even though it is not physiologic reality? - ScienceDirect
In vitro–in vivo extrapolation (IVIVE) for predicting human intestinal absorption and first-pass elimination of drugs: princip
![Discussions on the hepatic well‐stirred model: Re‐derivation from the dispersion model and re‐analysis of the lidocaine data | Semantic Scholar Discussions on the hepatic well‐stirred model: Re‐derivation from the dispersion model and re‐analysis of the lidocaine data | Semantic Scholar](https://d3i71xaburhd42.cloudfront.net/5b18898ebbe2342b515b13723085295e277a598b/5-Table1-1.png)